We bring personal medicine to you

Personal

  • Adjusting your medical prescription to your body’s individual dosage requirements
  • Calculating the ideal release profile for each of your medications based on your condition
  • Designing customised pills containing all your different medications, with individually tailored dosing and release rates

Adaptive

  • Building the 3D pill composed of multiple configurations of micropockets, each programmed to release their content at just the right time
  • Filling the micropockets with small discrete doses of your medications, ensuring identical application conditions to their original certification while revolutionizing their administration

Medicine

  • Keeping medications in their ideal therapeutic window, known to maximise efficiency and reduce side effects
  • Making polypharmacy adherence difficulties a thing of the past
  • Offering synergistic medication customised to patient and condition
  • Availability at local dispensing hubs

Revolutionary User
Experience

01

Doctor writes your prescription

02

PERaME selects the most suitable dosing and release profile to your individual needs

03

PERaME designs & produces your personalised medicine

04

By the time you get to your local pharmacy, your PERaME medication is ready for pickup

05

PERaME can continuously adjust your customised medicine to follow your condition

Overview

The PERAMEDIC project is developing the PERaME stand-alone drug formulation system for personalised medicine, offering locally prepared, individually customised, segmented release polypills, with an inherently digital technology drive. The system integrates several novel technologies: personal release profiles, in situ 3D printing of release matrix using adaptive toolpaths, and ultra-precise multichannel dosing of drugs into sealed microcompartments.

The PERaME system will be a tabletop-size pill/capsule micro-factory, using cartridges of drugs and bioresorbable polymer materials. Application scenarios would initially be clinical settings, then at later stage, pharmacy locations and local medical practices. For patients, a single pill each day would contain all their medication, complemented by supplements if needed, in quantities and release distributions that are optimised for the individual’s needs and condition.

Personalised drug formulation is a hot topic, but state-of-the-art approaches are limited by low scalability, high cost, and regulatory hurdles. Meanwhile, current polypill formulation efforts are hindered by the conditions of their production, such as high heat or liquid form use. Due to these difficulties, pill-split grooving is still the prevalent state-of-the-art in individual dosing.

The first development stage towards PERaME’s breakthrough solution will deliver a lab scale proof-of-concept prototype system to demonstrate the revolutionary potential and prove viability of the new approach to truly personalised medication.

First Phase Development Objectives

Pharma

  • Applicable suite of materials
  • Release Profile generation
  • Regulatory pathways

Printing

  • Microstructures suite and design
  • Pill Printing
  • Demo pill for use cases

Dosing

  • Standardised API feedstock
  • Precise deposition
  • Accurate positioning

System

  • Inspection system
  • Software control
  • Integrated demonstrator machine

Our Team

Team Perame

BULK
Balázs Havasi-Tóth

Balázs Havasi-Tóth

Intra muros Expert
bulkai.com/balazs-havasi-toth

Dr. Balázs Havasi-Tóth graduated with a Master’s degree from the Faculty of Mechanical Engineering at the Budapest University of Technology and Economics (BME) in 2013, and went on to earn his PhD in 2020 in the field of particle-based fluid dynamics modeling. Since then, he has been working as an Assistant Professor at the BME Department of Fluid Mechanics and within the HUN-REN Morphodynamics Research Group. His primary area of expertise is fluid dynamics modeling, as well as the study of the behavior and morphology of solid bodies in flows. Within this framework, he has conducted extensive fundamental research in both engineering and geological fields.

Balázs Istók

Balázs Istók

Intra muros Expert
bulkai.com/balazs-istok

Dr. Balázs Istók received his master’s degree from the Faculty of Mechanical Engineering of the Budapest University of Technology and Economics (BME) in 2001, and his doctoral degree in the field of gravity flow modeling in 2014. Since then, he has been working as an assistant professor at the Department of Fluid Mechanics of BME. His main field of expertise is fluid mechanics modeling and measurement technology. During his work, he designs and builds measurement equipment and performs measurements in the field of fluid mechanics.

Dr András Bulkai

Dr András Bulkai

CEO
bulkai.com/andras-bulkai

Dr. András Bulkai is a mechanical engineer with a strong academic and research background in engineering science. He earned his BEng with honours from Loughborough University in 2001, where he later completed his PhD in 2006. His doctoral research focused on finite element and variation analysis of threaded fasteners. In addition to his specialization, he has broader expertise in mechanics, dynamics, and CAD design. Dr. Bulkai has also worked in Hungary at private research centres, contributing to technology transfer initiatives that bridge research and industrial application.

Kristóf Bulkai

Kristóf Bulkai

CFO
bulkai.com/kristof-bulkai

Kristof is a Chartered Financial Analyst with more than twenty years’ experience investing in pharma, forestry, farming and water rights. He started his career at Goldman Sachs as a corporate finance analyst, before joining Griffin Capital Management as a discretionary trader, focusing on agriculture soft commodities and carbon markets, after which he set up and built out the water resource and agriculture-focused investment strategies division for Thames River Capital where he was a Partner. Prior to joining Thames River, he was a Partner at Liontrust Asset Management, where he also developed a sustainability overlay for the investment strategies he managed.

Kristof holds an MSc in Transition Economics from the London School of Economics and a BA in philosophy and politics from Durham University.

ATS
Clara Calvaruso

Clara Calvaruso is the Head of the Brussels Office at ATS Advisory, where she plays a central role in the company’s operations and has contributed to the development and management of numerous successful EU-funded projects. She completed her studies in Political Science and International Relations at the University of Siena before earning a Master’s degree in International and Diplomatic Studies in 2022.

Her strong interest in international affairs led her to gain experience abroad through an internship at the Italian Embassy in Vilnius, where she further developed her understanding of diplomacy and international cooperation. After moving to Budapest, Clara worked as a trainee at Corvinus University and at the Italian Chamber of Commerce, contributing to international business and institutional activities. Later relocating to Brussels, she worked as a Project Assistant managing EU-funded projects in the fields of renewable energy and energy storage, acquiring hands-on expertise in EU funding mechanisms, proposal writing, and project management.

Today, at ATS Advisory, she oversees the Brussels office operations while playing an active role in the development and implementation of European projects under programmes such as Horizon Europe, LIFE, Creative Europe, CEF, CERV. She is extensively involved in proposal development, including identifying funding opportunities, coordinating international consortia, drafting technical and strategic project sections, defining work packages and budgets, and ensuring alignment with EU priorities and evaluation criteria. She also supports project implementation activities, including partner coordination, communication with stakeholders and EU institutions, reporting, and the monitoring of project progress and deliverables across different project phases and sectors.

lacopo Castagnetta

lacopo Castagnetta

Lead Expert
atsadvisory.eu/iacopo-castagnetta

Iacopo Castagnetta is an EU Funding Expert at ATS Advisory, where he has been contributing to the development, writing, and management of European projects since September 2024. With a strong background in European affairs and sustainability, he has combined his academic interests with practical experience in international organisations, regional institutions, and consultancies. Throughout his career, he has worked for the Honorary Consulate of Greece in Venice, the Veneto Region Delegation in Brussels, the international organisation CIHEAM, and CLERENS, gaining extensive experience in EU project development, stakeholder engagement, policy analysis, and international cooperation.

Over the years, he has developed solid expertise in EU-funded programmes, particularly in sectors related to renewable energy, energy storage, sustainable agriculture, food and nutrition security, social empowerment, and climate action. He contributed to the steering and coordination of several European and AU-EU research and innovation networks, including ENSA, ELISAN, LEAP-Agri, FOSC, PRIMA, SCAR, and the BatteriesEurope Secretariat, supporting collaboration in sustainable food systems, agricultural innovation, and battery research ecosystems.

He also contributed to the organisation of institutional events and high-level workshops for the European Commission on Science Diplomacy and AU-EU cooperation. Alongside his professional activities, Iacopo is actively engaged in sustainability and climate-related initiatives. He holds a Bachelor’s degree in Political Sciences, International Politics and History and a Master’s degree in International Relations and Diplomacy from the University of Padua, and further specialised through executive programmes in energy management, sustainability, European affairs, and EU project design and management.

Orsolya Kurucz

Orsolya Kurucz is the CEO and Founder of ATS Advisory, a Brussels-based consultancy specialised in EU project and communication, EU policies, and strategic advisory services. With more than a decade of experience in European affairs, public administration, and international project development, she began her career in the Hungarian public administration in 2013 as an advisor on European Union dossiers at the Cabinet of the Minister for Public Administration and Justice, later continuing at the Cabinet of the Minister for Foreign Affairs and Trade.

She subsequently headed the department responsible for negotiating the EU’s 2021–2027 Multiannual Financial Framework, including directly managed EU funds. Throughout her career, she has developed relevant expertise in EU budget negotiations, policy coordination, and proposal development for directly managed EU programmes, while building a strong Brussels-based network connecting European institutions, private stakeholders, and international partners. In late 2022, she founded ATS Advisory, which has since grown into a recognised consultancy collaborating with more than 120 partners across Europe and supporting the preparation of many EU-funded projects across sectors including energy transition, digitalisation, defence, education, mobility, culture, and sustainability. Orsolya holds a Master’s degree in Political Science from Eötvös Loránd University in Hungary and completed the Accelerated Management Program at Solvay Brussels School in Belgium in 2023.

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